Chloroquine myopathy.

Open Access
Publisher Website
Google Scholar
Abstract
Clinical, biochemi-cal, electromyographic and histological findings indicated a myopathy in a patient who had been receiving chloroquine for 6 mo. The relation of the onset of symptoms, the recovery after this drug was stopped and the reversible corneal changes gave added evidence that chloroquine was the cause of the myopathy. Vacuolar changes in muscle are characteristic of lesions produced by chloroquine. These have been accompanied by glycogen accumulations. This suggests that the drug may injure the muscle by inhibiting enzymes involved in glycogen metabolism.