Studies on Mechanism of Atabrine Inhibition of ATPase Activity of the Myofibrils.

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Abstract
At low ionic strength, atabrine inhibition of myofibrillar ATPase activity was potentiated by Mg++. Ca++ counteracted atabrine inhibition in the absence but not in the presence of Mg++ The assumption of the occurrence of an Mg - atabrine coordination complex as the strong inhibitor is proposed as the best explanation of the experimental results. At high ionic strength, atabrine failed to inhibit Ca++ activated myofibrillar ATPase (myosin ATPase) with or without Mg++ being present.