The Frequency of Ovarian Tumours and of Estrus in Mice Treated with Roentgen Radiation and Hormones

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Abstract
Roentgen irradiation of 4-6 week old female mice with a dose of about 400 r produced no definite difference in the frequency of ovarian tumor or mammary carcinoma but increased the frequency of pulmonary tumor. In this respect irradiation of the entire animal had the same effect as irradiation with the hypophysis protected by a lead screen. Admn. of gonadotropic hormone to irradiated animals increased the frequency of pulmonary tumors at an earlier age. Admn. of estrogenic hormone to irradiated animals increased mortality. Animals irradiated with about 170 r became sterile and the frequency of estrus from the 10th week to the 10th month after irradiation was low. Gonadotropin treatment increased the frequency of estrus; histological examination showed a tendency to increased ovarian activity in the treated animals.