Endogenous Xenopus‐oocyte Ca‐channels are regulated by protein kinases A and C
- 2 March 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 299 (1) , 5-9
- https://doi.org/10.1016/0014-5793(92)80087-w
Abstract
Calcium entry into Xenopus oocyte occurs mainly through voltage-dependent calcium channels. These channels were characterized as belonging to a particular type of calcium channel insensitive to dihydropyridines, ω-conotoxin, and Agelenopsis aperta venom, but blocked by divalent cations (Co, Cd, Ni). Intracellular injection of cAMP, or bath application of phorbol ester, induced a marked increase in calcium current amplitude and a slowing of the inactivation time-course. Despite their different pharmacology, endogenous calcium channels, like cardiac or neuronal calcium channels, could be thus regulated by protein kinases A and C.Keywords
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