Graft-vs.-host-associated immune suppression is activated by recognition of allogeneic murine I-A antigens.

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Abstract
Several combinations of F1 hybrid mice were injected i.v. with parental spleen cells to determine the minimal H-2 differences between F1 and parent that are necessary to induce graft-vs.-host-associated immune suppression (GVH-associated suppression). At 7-14 days after injection, the spleens of the F1 mice were tested for cytotoxic T lymphocyte potential by in vitro sensitization against trinitrophenyl-self and H-2 alloantigens. Parental T lymphocytes must recognize I-A allogeneic determinants of the F1 recipient in order to induce suppression. Recognition of K or D alone or D with I region products other than I-A did not induce suppression. The recognition of I region without K and/or D and even the I-A difference between C57BL/6 and the B6.Cbm12 mutation resulted in immune suppression that was as potent as that resulting from the recognition of K, D and I together. The possible significance of this function for I-A antigens is discussed with respect to 3 clinical examples of immune suppression for which this phenomenon may be relevant.

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