Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: Is HPTP an intermediate?
- 7 November 1997
- journal article
- Published by Elsevier in Life Sciences
- Vol. 61 (24) , 2383-2390
- https://doi.org/10.1016/s0024-3205(97)00955-7
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboonLife Sciences, 1996
- Formation of pyridinium species of haloperidol in human liver and brainPsychopharmacology, 1996
- Studies on the Conversion of Haloperidol and Its Tetrahydropyridine Dehydration Product to Potentially Neurotoxic Pyridinium Metabolites by Human Liver MicrosomesChemical Research in Toxicology, 1996
- Metabolic Studies on Haloperidol and Its Tetrahydropyridine Analog in C57BL/6 MiceChemical Research in Toxicology, 1994
- High-performance liquid chromatographic method for the detection and quantitation of haloperidol and seven of its metabolites in microsomal preparationsJournal of Chromatography B: Biomedical Sciences and Applications, 1993
- Stereospecific reduction of haloperidol in human tissuesBiochemical Pharmacology, 1992
- Identification of potentially neurotoxic pyridinium metabolite in the urine of schizophrenic patients treated with haloperidolBiochemical and Biophysical Research Communications, 1991
- Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metaboliteToxicology Letters, 1991
- Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metaboliteChemical Research in Toxicology, 1991
- Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in ratsBiochemical and Biophysical Research Communications, 1990