THE EFFECT OF RU 41.740, AN IMMUNE MODULATING COMPOUND, IN THE PREVENTION OF ACUTE EXACERBATIONS IN PATIENTS WITH CHRONIC-BRONCHITIS
- 1 October 1986
- journal article
- research article
- Vol. 69 (4) , 235-241
Abstract
The effect of Biostim (UR 41.740), a new non-specific immune modulator, in reducing the number of acute exacerbations in patients with chronic bronchitis, was examined. One hundred and ninety-eight patients with chronic bronchitis stages 2 and 3 entered the study, which was conducted as a multicenter, double-blind, parallel three-group, placebo-controlled trial. The patients were randomised to placebo, Biostim 2 or 8 mg per day, and received treatment for 1 week every other week for 3 successive months during the winter 1983. A significant (p=0.005) reduction in the number of acute exacerbations was observed in the patients treated with Biostim 2 mg/day, where as no effect was observedin the placebo or 8 mg/day group. No serious side-effects were encountered.This publication has 3 references indexed in Scilit:
- ASSOCIATION OF DEFECTIVE MONOCYTE CHEMOTAXIS WITH RECURRENT ACUTE EXACERBATIONS IN CHRONIC OBSTRUCTIVE LUNG-DISEASE1986
- Influence of RU 41.740, a glycoprotein extract from Klebsiella pneumoniae, on the murine immune system. I. T-independent polyclonal B cell activation.The Journal of Immunology, 1984
- SERUM IMMUNOGLOBULIN-A IN CHRONIC BRONCHIAL INFLAMMATION1977