Petechial reaction following patch testing with cobalt

Abstract
A total of 132 patch-tested patients reacted with petechial reactions to CoCl2 1% in petrolatum; 23 were retested with various concentrations of Co. In about 60% of those retested the petechial reaction could be reproduced. Histopathological examination showed slight perivascular lymphocytic infiltration, swollen endothelium and extravasation of erythrocytes but no signs of vasculitis. In predisposed patients, the petechial reaction following patch testing could be the result of primary irritation.

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