ANDROGEN CONCENTRATIONS IN PROSTATE AND SERUM OF MALE AND FEMALE PRAOMYS-(MASTOMYS)-NATALENSIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (3) , 212-214
Abstract
The levels of androgens in the male prostate, seminal vesicles and serum, as well as in the female prostate and serum, were measured in the rodent Praomys (Mastomys) natalensis. Measurements were made in different age groups of both males and females using a sensitive radioimmunoassay. The values for serum testosterone [T] were 10 times greater in the male than in the female. The concentration of serum dihydrotestosterone [DHT] in the male was approximately one-tenth of the concentration of T. The recovery of DHT from the prostate in the female and seminal vesicle in the male was low and these values were not considered. The concentrations of T and DHT in the male prostate were 8.3 .+-. 0.5 and 20.0 .+-. 2.4 ng/g of wet tissue, respectively. The concentration of T in the female prostate, 7.1 .+-. 0.5 ng/g of wet tissue, was similar to that in the male. The female Mastomys has a prostate which exists in a low androgen environment; it is suggested that this could be used as an experimental model for studying hormonal effects on the prostate.

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