PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin
Open Access
- 1 October 2002
- journal article
- Published by Elsevier
- Vol. 277 (42) , 39062-39065
- https://doi.org/10.1074/jbc.c200469200
Abstract
No abstract availableKeywords
This publication has 34 references indexed in Scilit:
- The Role of Presenilins in γ-Secretase ActivityPublished by Elsevier ,2001
- Intramembrane proteolysis by presenilinsNature Reviews Molecular Cell Biology, 2000
- Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteasesNature Cell Biology, 2000
- Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cellsNature Cell Biology, 2000
- Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1Nature Cell Biology, 2000
- Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1Nature Cell Biology, 2000
- Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1Nature, 2000
- A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch SignalingJournal of Biological Chemistry, 1999
- Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activityNature, 1999
- Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor proteinNature, 1998