REGIONAL BLOOD-FLOW AND THE LOCALIZATION OF LYMPHOBLASTS IN THE SMALL-INTESTINE OF THE MOUSE .1. EXAMINATION OF NORMAL SMALL-INTESTINE

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (4) , 955-961
Abstract
125I-UdR-labeled mesenteric lymphoblast localization and the fraction of the cardiac output delivered to the small intestine was investigated in mice. When different small intestine regions were examined, the proportional cardiac output delivery and lymphoblast localization were found to vary along the small intestine length. A significant correlation between these 2 phenomena was identified when both lymphoblast localization and the cardiac output distribution within the small intestine were studied concurrently. The intestinal localization of populations of unseparated or T-enriched mesenteric lymphoblasts and peripheral lymphoblasts all showed a similar degree of correlation with the cardiac output fraction delivered along the small intestine in spite of marked differences in their proclivity to accumulate in the gut. Evidently there is an important relationship in normal animals between the lymphoblast accumulation level within a particular small intestine region and the delivery of blood-borne cells to that region. This relationship could provide a physiological explanation for an antigen-independent yet non-uniform effector cell distribution within the lamina propria of unimmunized animals.