Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli
- 1 November 1986
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 30 (5) , 777-780
- https://doi.org/10.1128/aac.30.5.777
Abstract
Subunit A and B proteins of DNA gyrase were separately purified from fluoroquinolone-resistant Escherichia coli GN14181 (MIC of ofloxacin, 100 .mu.g/ml) and susceptible strain KL-16. The supercoiling activities of reconstituted Ar+Br (r, resistant) and Ar+Bs (s, susceptible) were 250-fold more resistant to new fluoroquinolones than those of As+Bs and As+Br.This publication has 22 references indexed in Scilit:
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