Mode of Incomplete Cross-Resistance Among Pipemidic, Piromidic, and Nalidixic Acids
Open Access
- 1 August 1978
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 14 (2) , 240-245
- https://doi.org/10.1128/aac.14.2.240
Abstract
Spontaneous mutants with various patterns of resistance to pipemidic acid (PPA), piromidic acid (PA), and nalidixic acid (NAL) were isolated from Escherichia coli K-12. Most mutants were less resistant to PPA than to PA and NAL, and some mutants resistant to PA and NAL were hypersusceptible to PPA. As for the mutants tested, resistance to the drugs was conferred by mutations at nalA and new nal genes designated as nalC and nalD , both of which were located at about 82 min on the recalibrated map. Resistance to PA and NAL was due to decreased sensitivity of the bacterial DNA synthesizing system to them and insufficient drug transport, whereas resistance to PPA was only due to the former.This publication has 19 references indexed in Scilit:
- Nalidixic acid resistance: A second genetic character involved in DNA gyrase activityProceedings of the National Academy of Sciences, 1977
- Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzymeProceedings of the National Academy of Sciences, 1977
- Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.Proceedings of the National Academy of Sciences, 1976
- Coumermycin A1: a preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterizationBiochemistry, 1976
- Pipemidic Acid, a New Antibacterial Agent Active Against Pseudomonas aeruginosa : In Vitro PropertiesAntimicrobial Agents and Chemotherapy, 1975
- Pyrido[2,3-d]pyrimidine antibacterial agents. 3. 8-Alkyl- and 8-vinyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and their derivativesJournal of Medicinal Chemistry, 1975
- Studies on the Mechanism of Action of Nalidixic AcidAntimicrobial Agents and Chemotherapy, 1973
- A NONSPECIFIC INCREASE IN PERMEABILITY IN ESCHERICHIA COLI PRODUCED BY EDTAProceedings of the National Academy of Sciences, 1965
- 1,8-Naphthyridine Derivatives. A New Class of Chemotherapeutic AgentsJournal of Medicinal Chemistry, 1962
- Transduction of linked genetic characters of the host by bacteriophage P1Virology, 1955