Localization of a Neutralization Epitope of Foot-and-Mouth Disease Virus Using Neutralizing Monoclonal Antibodies
Open Access
- 1 September 1984
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 65 (9) , 1559-1566
- https://doi.org/10.1099/0022-1317-65-9-1559
Abstract
Neutralizing monoclonal antibodies raised against intact foot-and-mouth disease virus reacted with intact particles and with isolated VP1 from different strains from the same subtype. Prior treatment of the virus with either trypsin or with arginine-specific protease abolished recognition of both the virus and of VP1, suggesting the presence of a neutralization epitope in the central region of VP1 cleaved by these two enzymes. A synthetic peptide analogue of part of this region showed poor reactivity, however, with neutralizing antibody.This publication has 12 references indexed in Scilit:
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