Separation and Purification of Macrolides Using the Ito Multi-Layered Horizontal Coil Planet Centrifuge

Abstract
Four different microbially produced macrolide complexes have been separated and purified by chromatography on the Ito Horizontal Coil Planet Centrifuge. These antibiotics represent different subclasses which present a variety of separation problems. The separations required high resolution capabilities under mild chromatographic conditions.