Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination.
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (5) , 575-588
- https://doi.org/10.7164/antibiotics.40.575
Abstract
A novel complex of Gram-positive antibiotics has been isolated from the fermentation broth and mycelium of Dactylosporangium aurantiacum subsp. hamdenensis subsp. nov. The structures of these six compounds were deduced employing UV, MS, IR, and extensive 1D and 2D homonuclear and heteronuclear NMR experiments. Each component contained a highly unsaturated 18-membered macrolide ring. Components differed from one another by minor structural variations in the macrolide ring and by the number and esterification pattern of glycosidically bound sugars.This publication has 4 references indexed in Scilit:
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