Identification of an I-J+ antigen-presenting cell required for third order suppressor cell activation.
Open Access
- 1 January 1983
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 157 (1) , 353-358
- https://doi.org/10.1084/jem.157.1.353
Abstract
We have found that an I-J+ I-A- antigen-presenting cell (APC) is required for Ts3 activation in vivo. Together with the I-J restriction previously reported for Ts3 induction (Takaoki, M., M.-S. Sy, A. Tominaga, A. Lowy, M. Tsurifiji, B. Benacerraf, R. Finberg, and M. I. Greene, 1982, J. Exp. Med., 156:1325), it appears that this I-J+ APC is responsible for I-J restriction in the triggering of Ts3. This restriction may be exerted via a pre-Ts3 associative recognition of antigen and I-J encoded determinants, analogous to the T helper recognition of antigen in the context of I-A and I-E determinants.Keywords
This publication has 16 references indexed in Scilit:
- Spontaneous remission and acquired resistance to autoimmune encephalomyelitis (EAE) are associated with suppression of T cell reactivity: suppressed EAE effector T cells recovered as T cell lines.The Journal of Immunology, 1982
- Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.The Journal of Experimental Medicine, 1980
- Helper and suppressor T cell factorsSpringer Seminars in Immunopathology, 1980
- Antigen- and receptor-driven regulatory mechanisms. III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies.The Journal of Experimental Medicine, 1980
- Gene complementation in the T-lymphocyte proliferative response to poly (Glu55Lys36Phe9)n. A demonstration that both immune response gene products must be expressed in the same antigen-presenting cell.The Journal of Experimental Medicine, 1979
- The Induction of Cytolytic T Lymphocytes with Specificity for p-Azophenylarsonate Coupled Syngeneic CellsThe Journal of Immunology, 1978
- Regulation of delayed‐type hypersensitivity. III. Effect of cyclophosphamide on the suppressor cells for delayed‐type hypersensitivity to sheep erythrocytes in miceEuropean Journal of Immunology, 1978
- MECHANISMS OF REGULATION OF CELL-MEDIATED-IMMUNITY .2. INDUCTION AND SUPPRESSION OF DELAYED-TYPE HYPERSENSITIVITY TO AZOBENZENEARSONATE-COUPLED SYNGENEIC CELLS1978
- REGULATION OF IMMUNE-RESPONSE TO TUMOR ANTIGENS .3. CHARACTERIZATION OF THYMIC SUPPRESSOR FACTORS(S) PRODUCED BY TUMOR-BEARING HOSTS1977
- Structural and Serological Properties of Murine Ia AlloantigensImmunological Reviews, 1976