Efficient Synthesis of Fluorophosphonylated Alkyles by Ring-Opening Reaction of Cyclic Sulfates
- 31 July 2008
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (17) , 3895-3898
- https://doi.org/10.1021/ol801443s
Abstract
Ring-opening reactions of functionalized 1,2-cyclic sulfates and oxetanes with the phosphonodifluoromethyl carbanion are reported. This approach allows an easy access to fluorinated beta-hydroxyphosphonates that are building blocks in the synthesis of acyclic nucleosides. Synthesis of precursors of nucleoside phosphorylase inhibitors from these alcohols is described.Keywords
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