KIDNEY PRESERVATION BY HYPOTHERMIA USING A PERFUSATE MEDIUM WITH “INTRACELLULAR ION COMPOSITION”

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Abstract
Preservation of pig kidneys for 24 hours at 0°C has been studied using combined surface and short‐term initial perfusion cooling. As perfusate and storage medium a solution which mimics the intracellular ion composition has been used. Six consecutive experiments were performed. All the animals survived the transplantation and were observed for three months. Measurements of inulin, endogenous creatinine, urea and PAH clearances 10, 31 and 94 days after transplantation showed normal values as compared to a control group of autotransplanted, not long‐term preserved pig kidneys. Apart from a transitory reduction in the renal function during the first days after transplantation, the only permanent reduction found was a reduced maximal tubular excretion of PAH.