Function of Canine Renal Autografts After Extracorporeal Preservation

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Abstract
The function of extracorporeally preserved and replanted dog kidneys has been studied by determinations of serum creatinine, plasma clearances of PAH and inulin and blood flow using the xenon-133 wash-out technique. The kidneys were also examined histologically. After excision of the kidneys a cool and bloodless state was immediately induced by perfusion with 5% Rheoma-crodex solution followed by a buffered sugar solution both at +5°C temperature. After preservation periods between 5 and 96 h at this temperature replantation to the same animal was done. Seven animals were followed for 7 weeks and another group of 7 animals for 1 year. The results of the functional studies show that preservation for up until 20 h with this simple method is compatible with reasonable function of the solitary transplanted kidney. During the 1 year follow up most of the kidneys increased their function. The histologic examinations disclosed degenerative tubular changes, which healed during the 1 year follow up. Moderate signs of glomerular damage were noted which were not reversible during the 1-year follow-up.

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