Immune Response in vitro: Independence of "Activated" Lymphoid Cells

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Abstract
Antibody formation against sheep erythrocytes by mouse spleen cells in vitro requires interactions among antigen-treated macrophages and lymphoid cells in cell culsters for only a finite time. During this critical period of interaction, lymphoid cells become "activated" and thereafter can develop into antibody-producing cells independently of native antigen, macrophages, and cell clusters.

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