Protective Effect of a Sucrose Diet in Mercuric Chloride Poisoning

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Abstract
Rats fed only sucrose and vitamins for 3 weeks or more usually survive intravenous injection of 3 mg/ kg of mercuric chloride, a dose lethal for rats on a normal diet. Survivors returned to a normal diet grow rapidly and appear grossly normal. Survival occurs in the presence of a diminished rate of excretion of radiomercury and a renal concentration and content of radiomercury higher in sucrose-fed protected rats than in unprotected rats on a normal diet. Sucrose feeding itself causes slower excretion of mercury; evidence indicates that the renal binding of mercury in protected rats is greater than in the unprotected. Some sucrose-fed rats surviving an initial dose of mercuric chloride, survive additional doses after return to a normal diet. The excretion and renal content of mercury is not altered by ammonium chloride acidosis in chow-fed rats given mercuric chloride.

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