Recognition of Host Immune Activation by Pseudomonas aeruginosa
Top Cited Papers
- 29 July 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5735) , 774-777
- https://doi.org/10.1126/science.1112422
Abstract
It is generally reasoned that lethal infections caused by opportunistic pathogens develop permissively by invading a host that is both physiologically stressed and immunologically compromised. However, an alternative hypothesis might be that opportunistic pathogens actively sense alterations in host immune function and respond by enhancing their virulence phenotype. We demonstrate that interferon-γ binds to an outer membrane protein in Pseudomonas aeruginosa , OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin. These observations provide details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host.Keywords
This publication has 19 references indexed in Scilit:
- Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in MiceInfection and Immunity, 2004
- ENHANCED INTERFERON-?? PRODUCTION AND BACTERIAL CLEARANCE IN THE LIVER OF SPLENECTOMIZED MICE IN THE MODELS OF ESCHERICHIA COLI INJECTION OR INTESTINAL OBSTRUCTIONShock, 2004
- High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosaGastroenterology, 2004
- Comprehensive transposon mutant library of Pseudomonas aeruginosaProceedings of the National Academy of Sciences, 2003
- The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density‐dependency of the quorum sensing hierarchy, regulates rhl‐dependent genes at the onset of stationary phase and can be produced in the absence of LasRMolecular Microbiology, 2003
- Microarray Analysis of Pseudomonas aeruginosa Quorum-Sensing Regulons: Effects of Growth Phase and EnvironmentJournal of Bacteriology, 2003
- Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in cultureMicrobial Pathogenesis, 2002
- Advancing the Quorum in Pseudomonas aeruginosa : MvaT and the Regulation of N -Acylhomoserine Lactone Production and Virulence Gene ExpressionJournal of Bacteriology, 2002
- Genes Lost and Genes Found: Evolution of Bacterial Pathogenesis and SymbiosisScience, 2001
- Enhancement of Growth of Virulent Strains of Escherichia coli by Interleukin-1Science, 1991