IMMUNOPOTENTIATING EFFECTS OF AMPHOTERICIN-B .1. ENHANCED CONTACT SENSITIVITY IN MICE
- 1 January 1979
- journal article
- research article
- Vol. 123 (6) , 2878-2882
Abstract
Contact sensitivity responses to dinitrofluorobenzene (DNFB) or oxazolone were enhanced by amphotericin B (AmB) administration. This adjuvant effect of AmB was documented in mice by ear thickness measurements, ear histology and the 5-iodo-2''-deoxyuridine-125I ear assay. The optimum immunopotentiating effect of AmB required simultaneous administration at the time of skin sensitization. AmB-induced adjuvant effects were observed in adoptive transfer experiments in which syngeneic recipients of lymph node cells from animals sensitized with DNFB plus AmB gave stronger contact sensitivity responses than recipients of cells from mice sensitized with DNFB alone. AmB interfered with tolerance induction by i.v. dinitrobenzene sulfonic acid. Adjuvant effects of AmB may involve inhibition of suppressor cells or their precursors.This publication has 14 references indexed in Scilit:
- Augmentation of murine immune responses by amphotericin BCellular Immunology, 1977
- Antigen Handling by Guinea Pig Macrophages: Further Evidence for the Sequestration of Antigen Relevant for Activation of Primed T LymphocytesThe Journal of Immunology, 1977
- Response of Transplanted AKR Leukemia to Combination Therapy With Amphotericin Band 1,3-Bis(2-chloroethyl)-1-nitrosourea: Dose and Schedule Dependency2JNCI Journal of the National Cancer Institute, 1977
- Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) II. Cellular source and effect on responder and nonresponder mice.The Journal of Experimental Medicine, 1977
- Genetic control of contact sensitivity to oxazolone in inbred, H‐2 congenic and intra‐H‐2 recombinant strains of miceEuropean Journal of Immunology, 1977
- REGULATORY MECHANISMS IN CELL-MEDIATED IMMUNE-RESPONSES .3. ANTIGEN-SPECIFIC AND NONSPECIFIC SUPPRESSOR ACTIVITIES GENERATED DURING MLC1977
- Amphotericin B Induction of Sensitivity to Adriamycin, 1,3-bis (2-Chloroethyl)-1-Nitrosourea (BCNU) plus Cyclophosphamide in Human NeoplasiaAnnals of Internal Medicine, 1977
- Protective Effects of Amphotericin B Against Spontaneous and Transplantable Murine Tumors 2JNCI Journal of the National Cancer Institute, 1976
- CELL-MEDIATED IMMUNE-RESPONSE INVITRO .2. MECHANISM(S) INVOLVED IN SUPPRESSION OF DEVELOPMENT OF CYTOTOXIC LYMPHOCYTES1976
- Mitogenic Properties of Polyene Antibiotics for Murine B CellsScandinavian Journal of Immunology, 1976