MARKED STIMULATION OF LYMPHOCYTE-MEDIATED ATTACK ON TUMOR-CELLS BY TARGET-DIRECTED LIPOSOMES CONTAINING IMMUNE RNA
- 1 January 1978
- journal article
- research article
- Vol. 38 (4) , 1173-1176
Abstract
A marked stimulation of normal guinea pig lymphocytes was obtained by incubating them with liposomes that contained antibody to lymphocytes to provide homing of the vesicles and immune RNA isolated from guinea pigs immunized with syngeneic line 10 hepatocarcinoma cells. Tumor cell cytotoxicity was monitored by a 51Cr-release assay. This target cell delivery of immune RNA by liposomes produced a dose-dependent stimulation up to 12 times that achieved by in vitro methods with naked immune RNA.This publication has 5 references indexed in Scilit:
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