Effect of iC3b binding to immune complexes upon the phagocytic response of human neutrophils: synergistic functions between FcγR and CR3
Open Access
- 16 October 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 373 (3) , 189-192
- https://doi.org/10.1016/0014-5793(95)01036-e
Abstract
We compared the phagocytosis of immune complexes (IC) and iC3b‐opsonized derivatives (iC3b‐IC) by human neutrophils. The phagocytosis of iC3b‐IC via FcγR and CR3 was much greater than that of IC via FcγR alone. Adding ethanol to the cells decreased iC3b‐IC phagocytosis to that of IC, which was not affected by these reagents, suggesting that the enhanced phagocytosis is attributable to CR3‐mediated phospholipase D activation. The IC phagocytosis was inhibited more effectively by anti‐FcγIIIB, whereas the iC3b‐IC phagocytosis was partly inhibited only by anti‐FcγRII. The main FcγR might differ in IC and iC3b‐IC phagocytosis.Keywords
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