The (2-Cyano-1-phenyl)ethoxycarbonyl (CPEOC) Group-A New Protecting Group for Oligoribonucleotide Synthesis
- 1 May 1997
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 16 (5) , 801-808
- https://doi.org/10.1080/07328319708002955
Abstract
The (2-cyano-1-phenyl)ethoxycarbonyl (cpeoc) group was developed as a new base-labile protecting group for the 5′-OH function in solid-phase synthesis of oligoribonucleotide by the phosphor-amidite approach using the 4-methoxytetrahydropyran-4-yl (mthp) group for 2′-protection. The syntheses of the monomeric building blocks and the first oligoribonucleotides obtained by this approach are described.Keywords
This publication has 8 references indexed in Scilit:
- Nucleotides. Part XLIII. Solid‐phase synthesis of oligoribonucleotides using the 2‐dansylethoxycarbonyl ( 2‐{[5‐(dimethylamino)naphthalen‐1‐yl]sulfonyl}ethoxycarbonyl; dnseoc) group for 5′‐hydroxy protectionHelvetica Chimica Acta, 1994
- Synthesis of oligonucleotides via monomers with unprotected basesJournal of the American Chemical Society, 1991
- The Problem of 2′-Protection in Rapid Oligoribonucleotide SynthesisNucleosides and Nucleotides, 1987
- Synthesis of oligodeoxynucleotides and oligodeoxynucleotide analogs using phosphoramidite intermediatesTetrahedron, 1984
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesisTetrahedron Letters, 1981
- The synthesis of oligodeoxyprimidines on a polymer supportTetrahedron Letters, 1980
- Improved Procedures for the Preparation of Tetrahydro-4H-pyran-4-one and 5,6-Dihydro-4-methoxy-2H-pyran.Synthesis, 1975
- 4-methoxytetrahydropyran-4-ylTetrahedron, 1970