PITUITARY TUMORS

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Abstract
Cases (100) of pituitary tumor coming under the authors'' observation are reviewed. Sixty-five were males ranging from 10 to 80 years; and 35 females whose ages varied from 14 to 64 years constitute the series. Of this group of tumors, 37 were verified solid chromophobes; 10 verified cystic chromophobes; 14 unverified chromophile (acromegalics); 9 verified primary malignant chromophobes; and 2 verified metastatic carcinomas, one originating from the breast and the second from the nasopharynx. Eight-one operations were carried out in 66 patients, 15 of these representing re-explorations, with an overall operative mortality of 7.4%. Improvement in visual fields (55.4%) is greater than improvement in visual acuity (37.3%) in a given number of cases. A general discussion of the merits of surgery alone; irradiation only; and surgery plus irradiation is presented. The general clinical picture of pituitary disorders is outlined. Calcification occurring in pituitary tumors and "cerebral apoplexy" with immediate surgical treatment of the latter is emphasized. Pneumoencephalography and angiography afford the most accurate visual means of estimating the size of the tumors. Irradiation of the tumor is recommended if visual acuity and visual field changes are moderate. Surgery is advocated where vision is seriously jeopardized. A combination of the two methods was employed in the majority of cases. Substitution of proper hormonal therapy in all cases is essential.

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