EFFECTS OF DIETARY CYCLOPROPENE FATTY-ACIDS ON THE MIXED-FUNCTION OXIDASE SYSTEM OF THE RAINBOW-TROUT (SALMO-GAIRDNERI)

  • 1 January 1978
    • journal article
    • research article
    • Vol. 1  (6) , 773-778
Abstract
Dietary cyclopropene fatty acids (CPFA) in rainbow trout (S. gairdneri) decreased cytochrome P-450 and b5 content and NADPH-cytochrome c reductase activity 67.8%, 22.0% and 38.4%, respectively, compared to control-fed trout after 22 days. Dietary CPFA induced benzo(a)pyrene aryl hydrocarbon hydroxylase 37.5% over controls for the same time period. Microsomal protein levels were consistently lower in CPFA-fed trout. This pattern remained established in CPFA-fed trout for the duration of the experiment (74 days). A possible mechanism by which dietary CPFA act as co-carcinogens is suggested.