1-(2-METHOXYPHENYL)-4-ALKYLPIPERAZINES: EFFECT OF THE N-4 SUBSTITUENT ON THE AFFINITY AND SELECTIVITY FOR DOPAMINE D4 RECEPTOR
- 1 May 1997
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 7 (10) , 1327-1330
- https://doi.org/10.1016/s0960-894x(97)00218-7
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- D4 receptors and their antagonistsMedicinal Research Reviews, 1996
- Structure−Activity Relationship Studies on the 5-HT1A Receptor Affinity of 1-Phenyl-4-[ω-(α- or β-tetralinyl)alkyl]piperazines. 4Journal of Medicinal Chemistry, 1996
- 1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: Alkylamido and Alkylamino Derivatives. Synthesis, 5-HT1A Receptor Affinity, and Selectivity. 3Journal of Medicinal Chemistry, 1996
- 1-Phenyl-3-(aminomethyl)pyrroles as Potential Antipsychotic Agents. Synthesis and Dopamine Receptor BindingJournal of Medicinal Chemistry, 1995
- High Affinity and Selectivity on 5-HT1A Receptor of 1-Aryl-4-[(1-tetralin)alkyl]piperazines. 2Journal of Medicinal Chemistry, 1995
- Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationshipsJournal of Medicinal Chemistry, 1994
- Dopamine D4 receptors elevated in schizophreniaNature, 1993
- Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNABrain Research, 1991
- Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapineNature, 1991
- Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neurolepticsNature, 1990