Clofibrate raises human 24 h intragastric acidity but does not affect plasma gastrin concentration.

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Abstract
1. We studied the effects of acute oral dosing with clofibrate (500 mg four times daily) on 24 h intragastric acidity and plasma gastrin concentration in 12 healthy female subjects. 2. The 24 h integrated intragastric acidity rose from 429 mmol l‐1 h (95% CI 296‐479) before dosing to 527 mmol l‐1 h (95% CI 385‐664) on the day of dosing (+23%; P = 0.041), but no change was observed in the 24 h integrated plasma gastrin concentration: 420 pmol l‐1 h (95% CI 282‐499) before and 389 pmol l‐1 h (95% CI 249‐489) during dosing (P = 0.182). 3. We conclude that clofibrate has no acute antisecretory effect on the human stomach, and that human gastrin‐induced enterochromaffin‐like cell proliferation is unlikely with this drug.