THE EFFECT OF OESTROGEN ANTAGONISTS ON THE UPTAKE OF TRITIATED OESTRADIOL BY THE UTERUS AND VAGINA OF THE OVARIECTOMIZED MOUSE

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Abstract
SUMMARY: 17α-Ethyl-19-nortestosterone and MER-25 inhibited the early uptake of oestradiol by the uterus and vagina when both inhibitor and oestrogen were administered subcutaneously. The oestrogen-induced growth in the uterus and vagina was also inhibited by both compounds. Inhibition with 17α-ethyl-19-nortestosterone was greatest when it was injected at the same time as the oestradiol. It was not possible to obtain any inhibition of the oestrogenic response by systemic administration of dimethylstilboestrol although it seems that its oestrogenic metabolites will compete with the natural oestrogen for receptors in the target organ. With intravaginal injection MER-25 inhibited the rapid uptake of oestradiol while 17α-ethyl-19-nortestosterone had no effect. However, the activity retained in the vagina 20–180 min. after the injection of oestradiol was decreased by 17α-ethyl-19-nortestosterone.