Effect of Age and Sex on Lesions of the Esophagus in Buffalo Strain Rats Ingesting Diethylnitrosamine
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in Pathobiology
- Vol. 44 (2) , 65-72
- https://doi.org/10.1159/000163100
Abstract
Inbred Buffalo male and female rats, 4, 12, 24, and 52 weeks of age, ingested 0.0114% diethylnitrosamine in a semisynthetic diet. Both age and sex were important in the development of preneoplastic and neoplastic lesions of the esophagus. The 4-week-old male rats had notably more carcinomas of the esophagus than female rats of the same age; whereas, 12-week-old male rats had only slightly more carcinomas than the females. The incidence of esophageal lesions was about the same in 24-week-old males and females. Rats 52 weeks of age were not susceptible to esophageal carcinogenesis.This publication has 4 references indexed in Scilit:
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