Efficiency of High‐Flux Hemodialysis in the Treatment of Valproic Acid Intoxication

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Abstract
Recently, highly efficient (i.e., high volume) dialysis systems have been successfully introduced for the treatment of critically ill patients in the intensive care unit. They also can be a safer, more effective, and less costly alternative to traditional extracorporal techniques in the treatment of severe intoxication. This holds true even if the substance to be eliminated is believed to be a poor candidate for dialysis treatment. We report a case of successful treatment of potentially life‐threatening intoxication, with valproic acid (VPA) using a GENIUS® batch dialysis system for combined standard and extended high‐volume hemodialysis therapy. Concentration of VPA in the total collected dialysate were measured.