Reactivation of VX-Inhibited Cholinesterase by 2-Pam and Hs-6 in Rats

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Abstract
Atropinized rats intoxicated with ethyl-S-2-diisopropyl aminoethyl methyl phosphonothioate (VX), 15 mg/kg i.v., were divided into 3 groups and were treated with normal saline, 30 mg/kg of 2-PAM Cl and 30 mg/kg of HS-6, i.v. One h after administration of therapy they were decapitated and cholinesterase (ChE) activity was determined on blood, brain and diaphragm tissue. Both 2-PAM Cl and HS-6 markedly reactivted VX-inhibited blood and diaphragm ChE. Brain ChE activity was not significantly reactivated by either oxime. The effectiveness of these oximes in restoration of VX-inactivated ChE in vivo offers an explanation as to why conventional atropine/oxime therapy is so effective against VX intoxication.