Hb Cemenelum [α92 (FG4) Arg→Trp]: A hemoglobin variant of theα1/β2 interface that displays a moderate increase in oxygen affinity

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Abstract
Hb Cemenelum [α92 (FG4) Arg→Trp] carries a structural modification at the same position as Hb Chesapeake, a very high oxygen affinity variant. Hb Cemenelum was found in a French diabetic patient with no abnormal hematological features. The purified abnormal hemoglobin, like Hb J Cape Town, another variant of position α92(FG4), displayed only a 1.5-to 2-fold increased oxygen affinity and a reduced cooperativity. This hemoglobin demonstrates that, even for some key residues of theα1/β2 interface, the degree at which the functional properties are altered depends upon the specific residue occupying this position.