Pathogenicity of a Viral Strain (RPL12) Causing Avian Visceral Lymphomatosis and Related Neoplasms. I. Nature of the Lesions

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Abstract
Morphologic studies of lesions in chickens of varied breeding experimentally exposed to strain RPL12 virus reveal that four principal multicentric neoplastic entities are elicited by this strain. Two of these, erythroblastosis and visceral lymphomatosis, are highly malignant; one, osteopetrosis, eventually subsides; and one, hemangiomatosis, is unquestionably benign. The pathogenesis of erythroblastosis is compared and contrasted to that of visceral lymphomatosis. It is concluded that the latter is an extravascular neoplasia arising both intramedullarly and extramedullarly in a multicentric manner. Occasionally, a leukemic or leukemoid state is present; frequently, a secondary erythroid hyperplasia in the marrow is associated with this disease. Comparative studies on normal lymphoid foci, transplantable lymphoid tumors, field cases of the disease, and non-neoplastic pathologic proliferations suggest that the cell type in visceral lymphomatosis is a highly undifferentiated element of the lymphoid series. The experimental disease is equivalent to field cases of visceral lymphomatosis and to the entity described as lymphoid leukosis. The lesions in osteopetrosis and hemangiomatosis are briefly described and illustrated. Within each of these types of disease, the character of the lesions is not affected by such variables in the host as age, sex, and genetic background, or by the conditions of exposure to the virus. Nor is there any variation in this respect provided by other sources of serially propagated or freshly isolated virus.

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