Guinea pig maximization test open epicutaneous test and chamber test in induction of delayed contact hypersensitivity
- 1 October 1980
- journal article
- research article
- Published by Wiley in Contact Dermatitis
- Vol. 6 (5) , 341-344
- https://doi.org/10.1111/j.1600-0536.1980.tb04960.x
Abstract
A comparison was made between the guinea pig maximization test (GPMT), open epicutaneous test (OET) and chamber test (CT); the allergens were neomycin sulfate and propylene glycol (PG). The sensitization rate for neomycin in petrolatum was 35% in GPMT, 25% in OET and 25% in CT. The corresponding figures for neomycin in PG were 30% in GPMT, 45% in OET and 32% in CT. PG caused no hypersensitivity in 118 guinea pigs. As a hygroscopic, irritant and penetrating vehicle, PG facilitates the induction of delayed contact allergy, especially in OET.Keywords
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