STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. II. METHOD FOR THE QUANTITATIVE ASSAY OF SUPPRESSIVE ANTIMALARIAL ACTION IN FALCIPARUM MALARIA 123
Open Access
- 1 May 1948
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 27 (3 Pt 2) , 75-79
- https://doi.org/10.1172/jci101976
Abstract
The therapeutic response of blood-induced McClendon falciparum malaria to quinine has been shown to be related to the plasma quinine concn. and the duration of therapy, both of which factors are amenable to quantitative definition. Blood-induced malaria due to this strain provides a suitable test object for the quantitative appraisal of the relative suppressive activities of antimalarial agents. As in vivax malaria, the quinine-susceptibility of the erythrocytic phase differs in various strains of Plasmodium falciparum. Costa falciparum infections are more resistant to quinine than are those due to the McClendon strain.This publication has 1 reference indexed in Scilit:
- STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. I. METHOD FOR THE QUANTITATIVE ASSAY OF SUPPRESSIVE ANTIMALARIAL ACTION IN VIVAX MALARIA 123Journal of Clinical Investigation, 1948