Passive Protection Experiments with Brucella Antisera

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Abstract
Summary A passive protection test with brucella antibodies, based on the spleen counts technique, has been described. This test has been found more sensitive than that based on lethal challenge. Normal human sera have been shown to possess marked protecting power. Protective activity of human sera was considerably increased following vaccination with living streptomycin-dependent brucellae, or after natural disease. The bearing of these findings on several brucellosis problems has been briefly discussed. The author wishes to express his thanks to Prof. A. L. Olitzki for constant advice and encouragement; to Dr H. V. Muhsam, Department of Statistics, the Hebrew University, for generous help in the statistical analysis; and to Miss R. Avraam for technical assistance.