Induction of spectrin in erythroleukemic cells transformed by Friend virus.

Publisher Website
Google Scholar
Abstract
The presence and accumulation in murine erythroleukemic cells transformed by Friend virus of the erythrocyte membrane-associated protein spectrin was investigated. Spectrin was present in the uninduced cells and was induced 10- to 20-fold in dimethyl sulfoxide-treated differentiating cells. The intracellular concentration of spectrin reached a peak on the 3rd day of dimethyl sulfoxide treatment, after which it fell to levels found in mouse erythrocytes. The small subunit of spectrin was phosphorylated in the cells.