COMPARISON OF HISTOLOGIC AND IMMUNOLOGICAL HETEROGENEITY OF NON-HODGKINS LYMPHOMAS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 105  (2) , 97-106
Abstract
The lymphocyte surface marker phenotype in 11 selected [human] cases of non-Hodgkin''s lymphomas was determined with anti-immunoglobulin and mouse monoclonal antibodies against human lymphocyte antigens. A complement-mediated cell cytotoxicity assay on suspensions of the tumor cells was compared with an indirect immunoperoxidase technique on frozen tissue sections. Both methods gave good results in tumors with a uniform cell population, but the frozen section technique was superior in heterogeneous tumors. The 6 B-cell neoplasms were heterogeneous with respect to expression of surface immunoglobulin and Ia antigens. The 5 T-cell tumors were morphologically heterogeneous and highly variable in their expression of different T-cell specific antigens.