EFFECT OF DROPERIDOL ON DOPAMINE-INDUCED INCREASE IN EFFECTIVE RENAL PLASMA FLOW IN DOGS

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Abstract
The interaction between small doses of dopamine and droperidol on effective renal plasma flow was studied in dogs. Small doses of dopamine are known to produce renal vasodilatation by a dopaminergic mechanism and droperidol, a selective dopamine antagonist used in neuroleptanaesthesia, may attenuate this response. Effective renal plasma flow was measured non-invasively using 125Ihippuran. A 20-mm infusion of dopamine 2μg kg−1 min−1 significantly enhanced effective renal plasma flow (mean increase of 16% P−1 administered at the commencement of anaesthesia. It is concluded that droperidol reduces the renal vasodilatation induced by dopamine in anaesthetized dogs.