Relationship between Cell Cycle Stage in the Fertilized Egg of Mice and Repair Capacity for X-ray-induced Damage in the Sperm

1 January 1989

journal article
research article
Published by Taylor & Francis in International Journal of Radiation Biology

Vol. 56 (3) , 301-314
https://doi.org/10.1080/09553008914551471

Abstract

The potentiation effects of 3-aminobenzamide, caffeine, hydroxyurea and arabinofuranosyl cytosine on the yield of X-ray-induced chromosome aberrations of mouse sperm were examined at the first-cleavage metaphase, to clarify a correlation between chromosome aberrations and cell cycle dependency of repair capacity of the fertilized egg. The result provided evidence that there are two major types of DNA damage in X-irradiated sperm: (1) short-lived DNA lesions; the lesions are subject to repair inhibition by agents added in G₁ and are converted into chromosome-type aberrations during G₁, and (2) long-lived DNA lesions; the lesions persist until S phase and repair of the lesions is inhibited by caffeine, hydroxyurea and arabinofuranosyl cytosine in G₂.

Keywords

CELL CYCLE

This publication has 33 references indexed in Scilit:

The effect of 3-aminobenzamide on the frequency of X-ray- or neutron-induced chromosome aberrations in cycling or non-cycling human lymphocytes
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1985
Early mouse embryos exhibit strain variation in radiation-induced sister-chromatid exchange: relationship with DNA repair
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1984
Repair of the Ultraviolet-Irradiated Male Genome in Fertilized Mouse Eggs
Science, 1981
RELATIONSHIP BETWEEN CHROMOSOME ABERRATIONS IN THE FIRST-CLEAVAGE METAPHASES AND UNSCHEDULED DNA SYNTHESIS FOLLOWING PATERNAL MMS TREATMENT
The Japanese Journal of Genetics, 1980
Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.
Proceedings of the National Academy of Sciences, 1979
Expression of tem-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesis
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
Mouse sperm chromatin proteins: quantitative isolation and partial characterization
Biochemistry, 1977
Chromosome aberrations and dominant lethality of mouse embryos after paternal treatment with triethylenemelamine
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
Studies on chemically induced dominant lethality. I. The cytogenetic basis of MMS-induced dominant lethality in post-meiotic male germ cells
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
Synthesis and amino acid composition of basic proteins in mammalian sperm nuclei
Developmental Biology, 1975