Stereochemistry of Valine Biosynthesis
- 1 September 1980
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 110 (2) , 439-444
- https://doi.org/10.1111/j.1432-1033.1980.tb04885.x
Abstract
When .alpha.-aceto[1,3,5-13C3]lactate (2-hydroxy-2-methyl-3-oxo[1,3,5-13C3]butanoate) was incubated with a cell-free system prepared from Salmonella typhimurium, the valine produced was labeled in the C-4 pro-S position. This result proves that during the tertiary ketol rearrangement catalyzed by the reductoisomerase of the isoleucine-valine pathway, the methyl group transfer is to the re face of the trigonal centre at C-3 of .alpha.-acetolactate.This publication has 9 references indexed in Scilit:
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