RAPID AND SELECTIVE INDUCTION OF ERYTHROLEUKEMIA IN FEMALE DONRYU RATS BY CONTINUOUS ORAL-ADMINISTRATION OF 1-ETHYL-1-NITROSOUREA

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (9) , 3043-3046
Abstract
Three groups of female Donryu rats were given continuously 1-ethyl-1-nitrosourea, 400, 200 or 100 mg/liter, in their drinking water. Leukemias developed in 94 of 104 (92%) rats surviving more than 6 experimental weeks. Of the leukemias, erythroleukemias were induced most frequently, rapidly and selectively. Other types of leukemias were found in a few rats of the high dose group and, in some cases, in rats of the low dose group. Tumors were also induced in the digestive tract, mammary glands, ear duct and other organs, but their incidences were lower than 24%.