Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels

3 June 1991

journal article
Published by Wiley in FEBS Letters

Vol. 283 (2) , 259-262
https://doi.org/10.1016/0014-5793(91)80602-y

Abstract

A new 1,4‐dihydropyridine photoaffinity ligand, [³H]diazipine, has been assessed by binding and photolabeling, and compared with a currently used [³H]Diazipine reversibly binds to skeletal muscle Ca²⁺ channels with a similar affinity of [³H]azidopine, but [³H]diazipine labels the channels two times more efficiently and no release of the incorporated amount is observed after dithiothreitol treatment.

Keywords

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