MECHANISM OF THE INCREASED CAPILLARY PERMEABILITY INDUCED BY NONIONIC SURFACTANTS INJECTED INTRACUTANEOUSLY IN RABBITS

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Abstract
Pretreatment of the animal with diphenhydramine did not affect the extravasal leakage of the circulating Evans blue caused by Pegnol L-12, but inhibited slightly that caused by Tween 20. The extravasal leakage of the dye caused by Pegnol L-12 and Tween 20 was inhibited by the combined administration of Nal, ClO3, NO3, Br and Cl and also by Al, Br, Ca, K and Na chlorides in decreasing order. The combined administration of NaF enhanced the dye leakage. The combined administration of NaCl enhanced dye leakage and necrosis at the injection site of either surfactant. The extravasal dye leakage caused by Nikkol MYS-45 was enhanced by the combined administration of either Na salts, but was inhibited by AICI3. The extravasal dye leakage was increased more by the administration of the surfactants dissolved in physiological saline than the surfactants dissolved in isopropyl myristate. Feeding the animal a diet supplemented with cholesterol for 10 weeks resulted in the decreased manifestation of the extravasal dye leakage by the non-ionic surfactants. The mechanism of the extravasal dye leakage caused by the nonionic surfactants was discussed.