Studies of the Circulation and Respiration in a Patient with Anasarca Following Administration of Cortin and Sodium Chloride

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Abstract
Studies were made of the clinical manifestations and cardiorespiratory physiology in a patient without Addison''s disease who developed anasarca after the adm. of cortin and NaCl. The syndrome consisted in severe hypertension, generalized edema, effusions into body cavities, dyspnea orthopnea, profuse albumi-nuria and lowering of the serum protein level. The cardiovascular and pulmonary findings were those of pleural effusion; there was no evidence of congestive failure. Cortin appears to act as a general vascular toxin in a manner similar to the substances which cause glomeru-lonephritis and toxemia of pregnancy.