CORRELATION OF SERUM IGD LEVEL WITH CLINICAL AND HISTOLOGIC PARAMETERS IN HODGKIN DISEASE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (5) , 905-910
Abstract
The concentration of serum Ig[immunoglobulin]D was measured in 100 patients with Hodgkin disease; 65 had 3- to 50-fold increases in IgD levels. Several parameters influenced serum IgD concentration: IgD level in older patients (> 50 yr) was significantly lower than in the younger patients (< 18 yr). IgD concentration was significantly higher in splenectomized than in nonsplenectomized patients (P < 0.005). Therapy depressed IgD concentration, which fell to a value significantly lower than in untreated patients (P < 0.05). An interesting correlation was found between IgD levels and histologic type of the disease, lower levels being preferentially associated with the lymphocyte predominance type and higher with the lymphocyte depletion type. The logs of the means of these 2 groups were significantly different from the overall mean of the disease (P < 0.05 and P < 0.0005, respectively). Mixed cellularity and nodular sclerosing showed intermediate values.